AEW541 HCl
Product Specifications
CAS Number
2320261-63-8
Target
Others|||Autophagy|||IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors|||Autophagy|||Others
Bioactivity
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
Smiles
NC1=C2C(N(C=C2C3=CC(OCC4=CC=CC=C4)=CC=C3)[C@@H]5C[C@H](CN6CCC6)C5)=NC=N1.Cl.Cl
Molecular Formula
C27H31Cl2N5O
Molecular Weight
512.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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