SR1903 TFA
Product Specifications
CAS Number
2351884-03-0
Target
Others
Related Pathways
Others
Bioactivity
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor ? (ROR?) and liver X receptor (LXR) . It is an inverse agonist of ROR? and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor ? (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) . It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.
Smiles
C(C(O)=O)(F)(F)F.CC1=C(C2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)C=CC(CN3CCN(CC=4C=CN=CC4)CC3)=C1
Molecular Formula
C29H28F9N3O3
Molecular Weight
637.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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