GS-441524 HCl
Product Specifications
CAS Number
2378280-82-9
Target
Others, DNA/RNA Synthesis, SARS-CoV
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others, Microbiology/Virology
Bioactivity
GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.
Smiles
C(#N)[C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C=2N3C(=CC2)C(N)=NC=N3.Cl
Molecular Formula
C12H14ClN5O4
Molecular Weight
327.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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