JS25
Product Specifications
CAS Number
2411771-95-2
Target
BTK|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||Others|||Angiogenesis
Bioactivity
JS25 is a selective, covalent BTK inhibitor that deactivates BTK by chelating Tyr551, exhibiting an IC50 of 5.8 nM. It suppresses cancer cell proliferation, induces pronounced cell death, and enhances Burkitt's lymphoma murine xenograft model outcomes. Importantly, JS25 efficiently penetrates the blood-brain barrier.
Smiles
O=C1N(C2=C3C(C=C(C=C3)C4=CC=C(NS(C)(=O)=O)C=C4)=NC=C2C=C1)C5=CC(NC(C=C)=O)=CC(C)=C5
Molecular Formula
C29H24N4O4S
Molecular Weight
524.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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