PU-H71 HCl
Product Specifications
CAS Number
2095432-24-7
Target
HSP, DNA/RNA Synthesis
Related Pathways
Cytoskeletal Signaling, DNA Damage/DNA Repair, Metabolism, Cell Cycle/Checkpoint
Purity
0.9945
Bioactivity
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
Smiles
Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C(=NC=NC4N3CCCNC(C)C)N
Molecular Formula
C18H22ClIN6O2S
Molecular Weight
548.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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