YM-202074
Product Specifications
CAS Number
299900-83-7
Target
Others, GluR
Related Pathways
Others, Neuroscience
Bioactivity
YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells) .
Smiles
C(N(C)C1CCCCC1)(=O)C2=CN3C=4C(N=C3S2)=CC=C(CN(CCOC)C)C4
Molecular Formula
C22H30N4O2S
Molecular Weight
414.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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