Sagopilone
Product Specifications
CAS Number
305841-29-6
Target
Others, Microtubule Associated
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.
Smiles
C[C@@]12[C@@](O1)(C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](CC=C)[C@@H](O)[C@@H](C)CCC2)C=3C=C4C(=CC3)SC(C)=N4)[H]
Molecular Formula
C30H41NO6S
Molecular Weight
543.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
129844-FITC 100 µL
MRE11A (Double-strand Break Repair Protein MRE11A, Meiotic Recombination 11 Homolog 1, MRE11 Homolog 1, Meiotic Recombination 11 Homolog A, MRE11 Homolog A, HNGS1, MRE11) (FITC)
Sign In for Pricing
View Details 
MBS6336809-01 0.2 mL
PPWD1, ID (PPWD1, KIAA0073, Peptidylprolyl isomerase domain and WD repeat-containing protein 1, Spliceosome-associated cyclophilin) (APC)
Sign In for Pricing
View Details MBS6336809-02 5x 0.2 mL
PPWD1, ID (PPWD1, KIAA0073, Peptidylprolyl isomerase domain and WD repeat-containing protein 1, Spliceosome-associated cyclophilin) (APC)
Sign In for Pricing
View Details