R-130823
Product Specifications
CAS Number
321344-32-5
Target
Others
Related Pathways
Others
Bioactivity
R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM) . The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated adjuvant-induced hyperalgesia with rapid onset and long duration comparable to a cyclooxygenase-2 inhibitor, celecoxib.
Smiles
C(CC1=CC=CC=C1)N2CCC(C=3C(=C(NC3)C4=CC=C(F)C=C4)C=5C=CN=CC5)=CC2
Molecular Formula
C28H26FN3
Molecular Weight
423.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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