GW590735 sodium
Product Specifications
CAS Number
343322-50-9
Target
PPAR, Others
Related Pathways
DNA Damage/DNA Repair, Others, Metabolism
Bioactivity
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
Smiles
[O-]C(C(C)(C)OC(C=C1)=CC=C1CNC(C2=C(C)N=C(C3=CC=C(C=C3)C(F)(F)F)S2)=O)=O.[Na+]
Molecular Formula
C23H20F3N2NaO4S
Molecular Weight
500.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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TA811571AM 100 µL
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