PPI-2458
Product Specifications
CAS Number
431077-35-9
Target
Others, Aminopeptidase
Related Pathways
Others, Metabolism
Bioactivity
PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.
Smiles
C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(N[C@H]([C@@H](C)C)C(N)=O)=O)[C@H]2OC)[H])[C@@H](CC=C(C)C)O1
Molecular Formula
C22H36N2O6
Molecular Weight
424.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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