Betulonaldehyde
Product Specifications
CAS Number
4439-98-9
Target
Parasite|||Others
Related Pathways
Microbiology/Virology|||Others
Bioactivity
Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively) . Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives.
Smiles
C(=O)[C@]12[C@@]([C@@]3([C@](C)([C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)C(=O)CC5)[H])[H])CC1)[H])([C@H](C(C)=C)CC2)[H]
Molecular Formula
C30H46O2
Molecular Weight
438.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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