Verrucarin J

Product Specifications

CAS Number

4643-58-7

Target

ROS|||Antifungal|||Reactive Oxygen Species|||Anti-infection|||Apoptosis|||Others|||Virus Protease|||Antibiotic

Related Pathways

Microbiology/Virology|||Apoptosis|||Immunology/Inflammation|||Metabolism|||NF-?B|||Others

Bioactivity

Verrucarin J (Muconomycin B), derived from the Myrothecium fungus family, effectively generates reactive oxygen species (ROS) to induce apoptosis in various cancer cell lines, including A549, HCT 116, and SW-620. Besides its anticancer properties, it exhibits antifungal activity against Candida albicans and Mucor miehei. Furthermore, it notably inhibits the arenavirus Junin (JUNV) yield with an IC 50 of 1.2 ng/mL.