AG-012986 HCl
Product Specifications
CAS Number
486414-32-8
Target
Others
Related Pathways
Others
Bioactivity
AG-012986 HCl is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 HCl showed antiproliferative activities in vitro with IC (50) s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 HCl was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 HCl also showed dose-dependent retinoblastoma Ser (795) hypophosphorylation, cell cycle arrest, decreased Ki-67 tumor staining, and apoptosis in conjunction with antitumor activity.
Smiles
C(=O)(C=1SC(NC2=CC=C(C(N[C@@H](CN(C)C)C)=O)C=C2)=NC1N)C3=C(F)C=CC=C3F.Cl.Cl
Molecular Formula
C22H25Cl2F2N5O2S
Molecular Weight
532.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/1003704E-C587-4E5C-8D0F-31D9B3DFDE73/T69197
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6151178-01 0.1 mL
ALG8 (Probable Dolichyl Pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked Glycosylation Protein 8 Homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl G
Ask
View Details MBS6151178-02 5x 0.1 mL
ALG8 (Probable Dolichyl Pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked Glycosylation Protein 8 Homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl G
Ask
View Details NBP3-18119MFV500 0.1 mL
Mouse Monoclonal IL-37/IL-1F7 Antibody (B-N37) [mFluor Violet 500 SE]
Ask
View Details