Ki23057
Product Specifications
CAS Number
516523-31-2
Target
Others, Apoptosis
Related Pathways
Apoptosis, Others
Bioactivity
Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. (source: Cancer Lett. 2011 Aug 1;307 (1) :47-52) .
Smiles
O(C=1C2=C(C=C(OCCNCCO)C(OC)=C2)N=CC1)C3=CC=C(NC4=CC=C(C(C)(C)C)C=C4)C=C3
Molecular Formula
C30H35N3O4
Molecular Weight
501.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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