SAX-187 hydrochloride
Product Specifications
CAS Number
554403-08-6
Target
5-HT Receptor, Others
Related Pathways
Others, Neuroscience, GPCR/G Protein
Bioactivity
SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (SAX-187 hydrochloride: EC50=6.6 nM, Emax=93%) . In the rat frontal cortex, acute administration of SAX-187 hydrochloride (3-30 mg/kg, subcutaneous (s.c.) ) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
Smiles
S(=O)(=O)(N1C=2C(C(CCN)=C1)=CC=CC2)C=3N4C(=NC3Cl)SC=C4.Cl
Molecular Formula
C15H14Cl2N4O2S2
Molecular Weight
417.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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