PD-321852
Product Specifications
CAS Number
622856-21-7
Target
Others, Chk
Related Pathways
Others, Cell Cycle/Checkpoint
Bioactivity
PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.
Smiles
C(CCNC)N1C2=C(C3=C(C(=C2)C4=C(Cl)C=CC=C4Cl)C(=O)NC3=O)C=5C1=CC=C(O)C5
Molecular Formula
C24H19Cl2N3O3
Molecular Weight
468.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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