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Ellipticine quinone

Product Specifications

CAS Number

73326-98-4

Target

Dynamin, Reactive Oxygen Species, Others

Related Pathways

Metabolism, Others, NF-κB, Cytoskeletal Signaling, Immunology/Inflammation

Bioactivity

Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.) . Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.

Smiles

O=C1C2=C(C(=O)C=3C1=CN=CC3)NC=4C2=CC=CC4

Molecular Formula

C15H8N2O2

Molecular Weight

248.24

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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