UNC10112785
Product Specifications
CAS Number
748142-06-5
Target
Others
Related Pathways
Others
Bioactivity
UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures.
Smiles
N(C=1N=C(C2=C3N(N=C2)N=CC=C3)C=CN1)C4=CC=C(C(C)C)C=C4
Molecular Formula
C19H18N6
Molecular Weight
330.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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