XR9051
Product Specifications
CAS Number
762219-35-2
Target
Others, P-gp
Related Pathways
Others, Neuroscience, Membrane transporter/Ion channel
Bioactivity
XR9051 is as a potent modulator of P-glycoprotein (P-gp) -mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor of the binding of the cytotoxic to P-glycoprotein (EC50 = 1.4 +/- 0.5 nM) . XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein.
Smiles
O(C)C=1C=C2C(=CC1OC)CCN(CCC3=CC=C(NC(=O)C4=CC(/C=C\5/C(=O)N(C)/C(=C\C6=CC=CC=C6)/C(=O)N5)=CC=C4)C=C3)C2
Molecular Formula
C39H38N4O5
Molecular Weight
642.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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