Denibulin HCl
Product Specifications
CAS Number
779356-64-8
Target
Others|||Microtubule Associated
Related Pathways
Cytoskeletal Signaling|||Others
Bioactivity
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
Smiles
Cl.COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)[C@H](C)N)cc3)cc2[nH]1
Molecular Formula
C18H20ClN5O3S
Molecular Weight
421.9
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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