DAP-81
Product Specifications
CAS Number
794466-17-4
Target
Others, PLK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
Smiles
C(=O)(C1=C(NC=2C(N(=O)=O)=CN=C(NC3=CC=C(NC(C)=O)C=C3)N2)C=CC=C1)C4=CC=CC=C4
Molecular Formula
C25H20N6O4
Molecular Weight
468.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K7394107 1.0 µg DNA
Zmym3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
Sign In for Pricing
View Details LS119016-20ug 20 µg
AGAP8 (AGAP4) (NM_133446) Human Over-expression Lysate
Sign In for Pricing
View Details 
FAB330N-100UG 100 µg
Human CXCR1/IL-8RA Alexa Fluor 700 MAb (Clone 42705)
Sign In for Pricing
View Details 