DAP-81
Product Specifications
CAS Number
794466-17-4
Target
Others|||PLK
Related Pathways
Cell Cycle/Checkpoint|||Others
Bioactivity
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
Smiles
C(=O)(C1=C(NC=2C(N(=O)=O)=CN=C(NC3=CC=C(NC(C)=O)C=C3)N2)C=CC=C1)C4=CC=CC=C4
Molecular Formula
C25H20N6O4
Molecular Weight
468.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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