Porfiromycin
Product Specifications
CAS Number
801-52-5
Target
DNA Alkylator/Crosslinker, Others
Related Pathways
Others, DNA Damage/DNA Repair
Bioactivity
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
Smiles
O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4C)[H])[H]
Molecular Formula
C16H20N4O5
Molecular Weight
348.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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