Oxanosine
Product Specifications
CAS Number
80394-72-5
Target
Others, Adenosine Deaminase, Antibiotic
Related Pathways
Metabolism, Microbiology/Virology, Others
Bioactivity
Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 μg/ml, respectively, on peptone, but not nutrient, agar) . Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 μg/ml, respectively) . It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 μg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.
Smiles
O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)N=C(N)O1
Molecular Formula
C10H12N4O6
Molecular Weight
284.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
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