GPI-15427
Product Specifications
CAS Number
805242-85-7
Target
PARP, Others
Related Pathways
Others, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.
Smiles
O=C1C2=C3C(C=4C(OC3=CC=C2)=CC=C(CN5CCN(C)CC5)C4)=NN1
Molecular Formula
C20H20N4O2
Molecular Weight
348.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
ARP53741_P050-Biotin 100 µL
FSCN3 Antibody - middle region : Biotin (ARP53741_P050-Biotin)
Sign In for Pricing
View Details 
K4047108 1.0 µg DNA
Slc39a14 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details 
MBS7219066-01 48 Well
Monkey Prostaglandin E2 receptor EP3 subtype (PTGER3) ELISA Kit
Sign In for Pricing
View Details