GPI-15427
Product Specifications
CAS Number
805242-85-7
Target
PARP, Others
Related Pathways
Others, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.
Smiles
O=C1C2=C3C(C=4C(OC3=CC=C2)=CC=C(CN5CCN(C)CC5)C4)=NN1
Molecular Formula
C20H20N4O2
Molecular Weight
348.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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