Brivudine monophosphate
Product Specifications
CAS Number
80860-82-8
Target
Others
Related Pathways
Others
Bioactivity
Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF) . BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy.
Smiles
O=C1N(C=C(/C=C/Br)C(=O)N1)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)C2
Molecular Formula
C11H14BrN2O8P
Molecular Weight
413.12
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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