Pentoprilat
Product Specifications
CAS Number
82950-75-2
Target
Others
Related Pathways
Others
Bioactivity
Pentoprilat is a member of a series of l-glutarylindoline-2 (S) -carboxylic acid derivatives. Pentopril was evaluated as an inhibitor of a cell-free preparation of angiotensin-converting enzyme (ACE) isolated from rabbit lung. Intravenous administration of incremental doses of pentopril to anesthetized normotensive rats produced a dose-related inhibition of angiotensin I (AI) pressor responses. The onset of inhibition of the A1 pressor response was rapid, and substantial inhibition occurred at 5 min after administration of the ACE inhibitors. Pentopril hydrolyzed in vivo to the biologically active free-acid form of CGS 13934. It was well tolerated in normal volunteers and hypertensive patients. Pentopril was developed for the treatment of both hypertension and congestive heart failure. Pentopril produced little clinical improvement and no biochemical improvement in a patients with rheumatoid arthritis.
Smiles
C([C@@H](C[C@H](C(O)=O)C)C)(=O)N1C=2C(C[C@H]1C(O)=O)=CC=CC2
Molecular Formula
C16H19NO5
Molecular Weight
305.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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