Encequidar, HCl
Product Specifications
CAS Number
849675-88-3
Target
P-gp, Others
Related Pathways
Neuroscience, Others, Membrane transporter/Ion channel
Bioactivity
Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC (50) =0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC (50) =35.4nM) . Encequidar is currently under clinical trials.
Smiles
Cl.COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
Molecular Formula
C38H37ClN6O7
Molecular Weight
725.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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