FTR-1335
Product Specifications
CAS Number
851075-79-1
Target
Others
Related Pathways
Others
Bioactivity
FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains) . They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteristic of these drugs.
Smiles
N(C(=O)C1CCCC1)C=2SC=3C(N2)=CC=C(NC(=O)[C@H]4C[C@@H](NCC5=CC6=C(C=C5)C=CC=C6)CCC4)C3
Molecular Formula
C31H34N4O2S
Molecular Weight
526.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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