SKF89976A HCl
Product Specifications
CAS Number
85375-85-5
Target
GABA Receptor, Others
Related Pathways
Neuroscience, Others, Membrane transporter/Ion channel
Bioactivity
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively) . SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM) . It is able to pass the blood-brain barrier after systemic administration and is active in vivo.
Smiles
C(=CCCN1CC(C(O)=O)CCC1)(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C22H25NO2
Molecular Weight
335.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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