AMG-628, (S) -
Product Specifications
CAS Number
862269-92-9
Target
Others, TRP/TRPV Channel
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
AMG-628, (S) -, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
Smiles
O(C1=C2C(SC(NC(C)=O)=N2)=CC=C1)C=3C=C(N=CN3)N4CCN([C@@H](C)C5=CC=C(F)C=C5)CC4
Molecular Formula
C25H25FN6O2S
Molecular Weight
492.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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