XL-418
Product Specifications
CAS Number
871343-09-8
Target
Others
Related Pathways
Others
Bioactivity
XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K) . These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.
Smiles
BrC=1C2=C(N=CN=C2NN1)N3CCN(CC3)C4=CC(C(CCC(F)(F)F)=O)=CC(NCCN5CCCC5)=C4C
Molecular Formula
C26H32BrF3N8O
Molecular Weight
609.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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