XL-418
Product Specifications
CAS Number
871343-09-8
Target
Others
Related Pathways
Others
Bioactivity
XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K) . These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.
Smiles
BrC=1C2=C(N=CN=C2NN1)N3CCN(CC3)C4=CC(C(CCC(F)(F)F)=O)=CC(NCCN5CCCC5)=C4C
Molecular Formula
C26H32BrF3N8O
Molecular Weight
609.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-4092R-APC-Cy7 100 µL
BACH1 Polyclonal Antibody, APC-Cy7 Conjugated
Sign In for Pricing
View Details 
GTR15399484 1 Vial
Lentiviral human KIAA2012 sgRNA gene knockout kit - Lentiviral human KIAA2012 sgRNA gene knockout kit (100)
Sign In for Pricing
View Details VAng-Lsx04436-1mgEcoli 1 mg (E. coli)
Recombinant Legionella Pneumophila nuoI Protein (aa 1-166) (strain Lens)
Sign In for Pricing
View Details 
TP302532M 100 µg
Mesothelin (MSLN) (NM_005823) Human Recombinant Protein
Sign In for Pricing
View Details K0373002 1.0 µg DNA
CCDC7 sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details