Fostriecin (free base)
Product Specifications
CAS Number
87810-56-8
Target
Phosphatase, Others, Antibacterial, Topoisomerase, Antibiotic
Related Pathways
Microbiology/Virology, Metabolism, DNA Damage/DNA Repair, Others
Bioactivity
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively) . It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.
Smiles
[C@H]([C@](/C=C/[C@@H]1OC(=O)C=CC1)(C)O)(C[C@H](/C=C\C=C/C=C/CO)O)OP(=O)(O)O
Molecular Formula
C19H27O9P
Molecular Weight
430.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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