ZK-Thiazolidinone
Product Specifications
CAS Number
891849-87-9
Target
Others
Related Pathways
Others
Bioactivity
ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 ?M) . ZK-Thiazolidinone impairs centrosome maturation.
Smiles
C(C(NCC(F)(F)F)=O)(C#N)=C1N(CC)C(=O)C(=CNC2=CC(CCN3CCCC3)=CC=C2)S1
Molecular Formula
C23H26F3N5O2S
Molecular Weight
493.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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