Rolapitant hydrochloride hydrate

Product Specifications

CAS Number

914462-92-3

Target

Neurokinin receptor|||Others

Related Pathways

Neuroscience|||Others|||GPCR/G Protein

Bioactivity

Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP) . This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV) . The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy.

Smiles

O.Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

Molecular Formula

C25H29ClF6N2O3

Molecular Weight

554.95

Shipping Conditions

Cool pack

Storage Temperature

-20°C