HKI-357 dimaleate
Product Specifications
CAS Number
915942-25-5
Target
Others|||EGFR
Related Pathways
Others|||JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
Smiles
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Molecular Formula
C39H37ClFN5O11
Molecular Weight
806.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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