HKI-357 dimaleate

Product Specifications

CAS Number

915942-25-5

Target

Others|||EGFR

Related Pathways

Others|||JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Bioactivity

HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

Smiles

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

Molecular Formula

C39H37ClFN5O11

Molecular Weight

806.2

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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