AKI-001
Product Specifications
CAS Number
925218-37-7
Target
Others
Related Pathways
Others
Bioactivity
AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.
Smiles
C(C)N1C=2C=C3C4=C(NC3=CC2C(C)(C)C1=O)C=5C(CCC4)=C(C)NN5
Molecular Formula
C21H24N4O
Molecular Weight
348.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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