KCN1
Product Specifications
CAS Number
927823-01-6
Target
HIF/HIF Prolyl-Hydroxylase, Others, Histone Acetyltransferase
Related Pathways
Chromatin/Epigenetic, Metabolism, Others
Bioactivity
KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE) -dependent manner. KCN1 potently inhibited the growth of subcutaneous malignant glioma tumor xenografts with minimal adverse effects on the host.
Smiles
N(S(=O)(=O)C1=CC(OC)=C(OC)C=C1)(CC=2C=C3C(=CC2)OC(C)(C)C=C3)C4=CC=CC=C4
Molecular Formula
C26H27NO5S
Molecular Weight
465.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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