VJ115
Product Specifications
CAS Number
929256-79-1
Target
Others
Related Pathways
Others
Bioactivity
VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis.
Smiles
C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5
Molecular Formula
C23H24N2O
Molecular Weight
344.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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