Adriforant
Product Specifications
CAS Number
943057-12-3
Target
Histamine Receptor
Related Pathways
Neuroscience|||Immunology/Inflammation|||GPCR/G Protein
Purity
0.9984
Bioactivity
Adriforant (PF-3893787, ZPL-3893797) is a competitive H4 (histamine receptor 4) antagonist that antagonizes histamine-induced phosphorylation of ERK, normalizes histamine-induced transcriptional changes in mast cells and reduces histamine-dependent Ca2+ fluxes in neurons, which alleviates itching and skin inflammation in mice
Smiles
N(C)[C@H]1CN(CC1)C=2C=C(NCC3CC3)N=C(N)N2
Molecular Formula
C13H22N6
Molecular Weight
262.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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