RO5068760
Product Specifications
CAS Number
947182-25-4
Target
Others
Related Pathways
Others
Bioactivity
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP) -competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.
Smiles
[C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=C(F)C=C(I)C=C2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OC[C@@H](CO)O)C=C4
Molecular Formula
C28H27FIN3O6
Molecular Weight
647.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2573218 200 µL
Zebrafish her4.4 Rabbit Polyclonal Antibody (Cy3)
Sign In for Pricing
View Details 
MBS2081016-01 0.1 mL
FITC-Linked Polyclonal Antibody to Delta Like Protein 4 (dLL4)
Sign In for Pricing
View Details MBS2081016-02 0.2 mL
FITC-Linked Polyclonal Antibody to Delta Like Protein 4 (dLL4)
Sign In for Pricing
View Details MBS2081016-03 0.5 mL
FITC-Linked Polyclonal Antibody to Delta Like Protein 4 (dLL4)
Sign In for Pricing
View Details MBS2081016-04 1 mL
FITC-Linked Polyclonal Antibody to Delta Like Protein 4 (dLL4)
Sign In for Pricing
View Details