RO5068760
Product Specifications
CAS Number
947182-25-4
Target
Others
Related Pathways
Others
Bioactivity
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP) -competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 ?M in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.
Smiles
[C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=C(F)C=C(I)C=C2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OC[C@@H](CO)O)C=C4
Molecular Formula
C28H27FIN3O6
Molecular Weight
647.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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