Beclabuvir HCl
Product Specifications
CAS Number
958002-36-3
Target
Others, HCV Protease
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Others
Bioactivity
Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. B
Smiles
Cl.[H][C@@]12C[C@@]1(Cn1c(c(C3CCCCC3)c3ccc(cc13)C(=O)NS(=O)(=O)N(C)C)-c1ccc(OC)cc21)C(=O)N1C2CCC1CN(C)C2
Molecular Formula
C36H46ClN5O5S
Molecular Weight
696.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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