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OK-1035

Product Specifications

CAS Number

98293-88-0

Target

Others

Related Pathways

Others

Bioactivity

OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.

Smiles

C(=NN)C1=C(C=C(C#N)C(=O)N1)C=2C=CN=CC2

Molecular Formula

C12H9N5O

Molecular Weight

239.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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