OK-1035
Product Specifications
CAS Number
98293-88-0
Target
Others
Related Pathways
Others
Bioactivity
OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.
Smiles
C(=NN)C1=C(C=C(C#N)C(=O)N1)C=2C=CN=CC2
Molecular Formula
C12H9N5O
Molecular Weight
239.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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