PPMC

The alpha-adrenoceptors blocking effect of (N-piperidinomethyl) -2-chromanne was studied in vivo and in vitro in the rat. In the pithed rat, (N-piperidinomethyl) -2-chromanne (1 mg/kg i.v.) antagonized the pressor effects induced by alpha agonists. (N-piperidinomethyl) -2-chromanne competitively antagonized the pressor effects of M7 (alpha 2-agonist) and cirazoline (alpha 1-agonist) . (N-piperidinomethyl) -2-chromanne antagonized the inhibitory effects of clonidine on presynaptic alpha 2-receptors in stimulated pithed rats.