JB061
Product Specifications
Target
Myosin
Related Pathways
Cytoskeletal Signaling
Purity
0.9967
Bioactivity
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 ?M (Cardiac muscle myosin), 9.1 ?M (Skeletal muscle myosin), and >100 ?M (Smooth muscle myosin II) . It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 ?M. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 ?M.
Smiles
COc1cccc(C\N=C(/C)c2c(O)c3ccccc3oc2=O)c1
Molecular Formula
C19H17NO4
Molecular Weight
323.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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